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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC7 All Species: 24.24
Human Site: T559 Identified Species: 66.67
UniProt: O00311 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00311 NP_001127891.1 574 63888 T559 L N P A S R I T A E E A L L H
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001097186 574 63766 T559 L N P A S R I T A E E A L L H
Dog Lupus familis XP_537080 756 83548 T741 L N P A S R I T A E E A L L H
Cat Felis silvestris
Mouse Mus musculus Q9Z0H0 564 62734 T549 L N P A S R I T A E A A L L H
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521163 410 45484 T396 T I R G S R E T I Q A A K T F
Chicken Gallus gallus XP_422347 564 62394 A550 N P A T R I T A K D A L L H P
Frog Xenopus laevis NP_001081878 483 53563 T469 M N P A T R I T A E E A L I H
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785538 591 65818 T577 L D P H K R I T A E Q A L K H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P06243 507 58302 S493 E D D V V S S S E A D L L D K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.8 68.9 N.A. 78 N.A. N.A. 61.3 67.2 55.4 N.A. N.A. N.A. N.A. N.A. 36.7
Protein Similarity: 100 N.A. 97.7 71.5 N.A. 84.8 N.A. N.A. 65.6 78.7 66.9 N.A. N.A. N.A. N.A. N.A. 54.4
P-Site Identity: 100 N.A. 100 100 N.A. 93.3 N.A. N.A. 26.6 6.6 80 N.A. N.A. N.A. N.A. N.A. 66.6
P-Site Similarity: 100 N.A. 100 100 N.A. 93.3 N.A. N.A. 33.3 13.3 100 N.A. N.A. N.A. N.A. N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 39.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 12 56 0 0 0 12 67 12 34 78 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 23 12 0 0 0 0 0 0 12 12 0 0 12 0 % D
% Glu: 12 0 0 0 0 0 12 0 12 67 45 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % F
% Gly: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 12 0 0 0 0 0 0 0 0 0 12 67 % H
% Ile: 0 12 0 0 0 12 67 0 12 0 0 0 0 12 0 % I
% Lys: 0 0 0 0 12 0 0 0 12 0 0 0 12 12 12 % K
% Leu: 56 0 0 0 0 0 0 0 0 0 0 23 89 45 0 % L
% Met: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 12 56 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 12 67 0 0 0 0 0 0 0 0 0 0 0 12 % P
% Gln: 0 0 0 0 0 0 0 0 0 12 12 0 0 0 0 % Q
% Arg: 0 0 12 0 12 78 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 56 12 12 12 0 0 0 0 0 0 0 % S
% Thr: 12 0 0 12 12 0 12 78 0 0 0 0 0 12 0 % T
% Val: 0 0 0 12 12 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _